Abstract: . . .  psycholinguistics Page 1 PLINX204 PSYCHOLINGUISTICS LANGUAGE ACQUISITION – 2006 - 6 Molecular genetic evidence (1) FOXP2 – the KE family revisited Basic reading: Marcus & Fisher, 2003 Additional reading: Plomin et al, 2000; Newbury et al, 2005; Liegois et al, 2003; Shu et al, 2005. 1. Background: a. The epidemiology of the KE family (handout 4). A three-generation family of over 30 members, half of whom have a clinically diagnosed speech and language problem, traceable to the maternal grandparent. b. Elementary genetics shows that this is un controversially a case of classical Mendelian inheritance – autosomal dominant transmission - with an identifiable polymorphism. c. Pleiotropy is common but there may be polygenic considerations (as found in e.g. autism) and also epigenetic factors to take into account. (That is, despite the Mendelian pedigree, lots of . . .
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